Does driving a car in ONE state with registration tags from ANOTHER make you a suspicious person?

Does driving a car in ONE state with registration tags from ANOTHER make you a suspicious person? In this case, Vasquez was a citizen of Colorado, driving alone on Interstate 70 from Colorado through Kansas, in the middle of the night, in a recently purchased, older-model car.

We hope Vasquez was driving this wood-paneled war wagon, but he probably wasn’t. Oh, and there is the map of I-70. It’s a big interstate! “[T]hat Vasquez was driving on I-70 does not make his otherwise innocent conduct suspicious. I-70 is a major corridor between Colorado and the East Coast. It could equally be said that it is suspicious to not drive from Colorado to Maryland along I-70.”

http://www.ca10.uscourts.gov/opinions/14/14-3278.pdf